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. 1963 Aug:3:293-300.
doi: 10.1016/s0022-4804(63)80009-8.

A COMPARISON OF THE HYPOGLYCEMIC EFFECT OF INSULIN WITH SYSTEMIC VENOUS AND PORTAL VENOUS ADMINISTRATION

T E STARZL, W A SCANLAN, H M YANOF, F H THORNTON, R M WENDEL, B STEARN, R E LAZARUS, W MCALLISTER, W C SHOEMAKER

A COMPARISON OF THE HYPOGLYCEMIC EFFECT OF INSULIN WITH SYSTEMIC VENOUS AND PORTAL VENOUS ADMINISTRATION

T E STARZL et al. J Surg Res. 1963 Aug.
No abstract available

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Figures

Fig. 1
Fig. 1
Experimental preparation showing transposition of the portal vein and inferior vena cava and the positions of the catheters used. 1, Foreleg catheter for systemic insulin infusion. 2, Catheter in side branch of femoral vein for infusion of insulin via inferior vena cava which then leads into portal vein and liver ( intraportal route). 3, Sampling catheter introduced through side branch of femoral vein on opposite side and threaded up the vena cava through vascular anastomosis into the portal vein. 4, Sampling catheter introduced into side branch of femoral artery and threaded into aorta.
Fig. 2
Fig. 2
Effect of insulin infusion (0.0007unit/kg./min.)upon arterial plasma glucose concentration given by systemic and intraportal routes. Mean values and standard errors are represented by dots and vertical bars respectively. The apparent difference in late effect with the two routes was not statistically significant.
Fig. 3
Fig. 3
Effect of insulin infusion (0.0012 unit/kg./min.) upon arterial plasma glucose with systemic compared to portal administration of insulin. Mean values and standard errors are represented by dots and vertical bars respectively. There was no significant difference in effect with the two routes of infusion.
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References

    1. Bell ET. The incidence and significance of degranulation of the beta cells in islets of Langerhans in diabetes mellitus. Diabetes. 1953;2:125. - PubMed
    1. Boggild DH. Experiments on insulin administration through the portal system in dogs. Acta path et microbial scandinav. 1928;5:118.
    1. Campbell D, Morgan TU. On the absorption of insulin from the digestive tract. J Pharmacol & Exper Therap. 1933;49:450.
    1. Collens WS, Murlin JR. Hyperglycemia following portal injection of insulin. Proc Soc Exper Biol & Med. 1928;26:485.
    1. Dohan FC, Lukens FDW. Experimental diabetes produced by the administration of glucose. Endocrinology. 1948;42:244. - PubMed

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