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. 1963 Oct 18;142(3590):400-1.
doi: 10.1126/science.142.3590.400.

GENETIC DIFFERENCES IN ANTIBODY PRODUCTION TO DETERMINANT GROUPS ON INSULIN

E R ARQUILLA, J FINN

GENETIC DIFFERENCES IN ANTIBODY PRODUCTION TO DETERMINANT GROUPS ON INSULIN

E R ARQUILLA et al. Science. .

Abstract

Highly inbred strain 2 guinea pigs can produce antibodies to portions of the insulin molecule to which strain 13 guinea pigs cannot produce antibodies. Such differences were not observable within either strain. Consequently it is probable that genetic factors regulate antibody production with respect to the determinant groups toward which antibodies are directed.

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