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. 1963 Oct;19(1):71-7.
doi: 10.1083/jcb.19.1.71.

UPTAKE OF MAMMALIAN CHROMOSOMES BY MAMMALIAN CELLS

A BENDICH, E BORENFREUND, O L ITTENSOHN, D J HUTCHISON

UPTAKE OF MAMMALIAN CHROMOSOMES BY MAMMALIAN CELLS

A BENDICH et al. J Cell Biol. 1963 Oct.

Abstract

Chromosomes isolated from mouse leukemia L1210 cells were taken up by mouse macrophages, HeLa cells, and rat embryo fibroblasts following simple exposure in vitro. The process, which resembles pinocytosis or phagocytosis, was traced by autoradiography of chromosomes prelabeled with thymidine-H(3), and by staining techniques and phase contrast microscopy. During the first six hours, the uptake of chromosomes was restricted to the cytoplasm, but there was some evidence of penetration into the nucleus after 16 and 26 hours of exposure. Treatment of rat fibroblasts with glucose and insulin markedly enhanced the uptake of chromosomes, whereas iodoacetate inhibited their penetration.

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References

    1. Exp Cell Res. 1961 Jan;22:137-45 - PubMed
    1. Biochim Biophys Acta. 1956 Mar;19(3):583 - PubMed
    1. Exp Cell Res. 1962 Mar;26:534-40 - PubMed
    1. Science. 1961 Feb 10;133(3450):381-2 - PubMed
    1. Exp Cell Res. 1961 Nov;25:480-4 - PubMed

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