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Review
. 1992 Sep;17(9):877-85.
doi: 10.1007/BF00993263.

Quantitative aspects of reactive gliosis: a review

W T Norton  1 , D A Aquino, I Hozumi, F C Chiu, C F Brosnan
Affiliations
Review

Quantitative aspects of reactive gliosis: a review

W T Norton et al. Neurochem Res. 1992 Sep.

Abstract

Recent studies of gliosis in a variety of animal models are reviewed. The models include brain injury, neurotoxic damage, genetic diseases and inflammatory demyelination. These studies show that reactive gliosis is not a stereotypic response, but varies widely in duration, degree of hyperplasia, and time course of expression of GFAP immunostaining, content and mRNA. We conclude that there are different biological mechanisms for induction and maintenance of reactive gliosis, which, depending on the kind of tissue damage, result in different expressions of the gliotic response.

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