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. 1964 Feb 7;143(3606):581-3.
doi: 10.1126/science.143.3606.581.

ALLELIC MAPPING IN YEAST BY X-RAY-INDUCED MITOTIC REVERSION

T R MANNEY, R K MORTIMER

ALLELIC MAPPING IN YEAST BY X-RAY-INDUCED MITOTIC REVERSION

T R MANNEY et al. Science. .

Abstract

A new method for determining the sequence of mutational sites is based on the linear dose-effect relation for x-ray induction of allelic recombination in Saccharomyces cerevisiae. Mutations at two loci have been mapped by this method. The use of x-ray simplifies allelic mapping and greatly increases its sensitivity.

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