Genetic alterations in head and neck cancer
Affiliations
- PMID: 1408191
Item in Clipboard
Genetic alterations in head and neck cancer
Otolaryngol Clin North Am.
1992 Oct.
Abstract
Mutations of the ras gene family appear to be an uncommon genetic alteration in SCCHN. A common region of DNA amplification on chromosome 11q13 has been identified in SCCHN. A cluster of proto-oncogenes (int-2, hst-1, bcl-1, prad-1) has been localized to the 11q13 region. Studies are needed to determine the critical genes in 11q13 whose expression drive the amplicon. Mutations of the p53 tumor suppressor gene are the most common genetic alteration in SCCHN. The hope is that dysregulated oncogenes or tumor suppressor genes may be targets for specific therapy.
Similar articles
-
Applications of molecular epidemiology to head and neck cancer.Otolaryngol Clin North Am. 1997 Feb;30(1):21-34. Otolaryngol Clin North Am. 1997. PMID: 8995134 Review.
-
Mutation of p53 in head and neck squamous cell carcinoma correlates with Bcl-2 expression and increased susceptibility to cisplatin-induced apoptosis.Head Neck. 2004 Oct;26(10):870-7. doi: 10.1002/hed.20029. Head Neck. 2004. PMID: 15390206
-
Frequent deletion and down-regulation of ING4, a candidate tumor suppressor gene at 12p13, in head and neck squamous cell carcinomas.Gene. 2005 Aug 15;356:109-17. doi: 10.1016/j.gene.2005.02.014. Gene. 2005. PMID: 15935570
-
Genetic instabilities of chromosome 9, 17 and accumulation of p53 overexpression during multistage tumorigesis in head and neck cancer.J Med Assoc Thai. 1996 Dec;79 Suppl 1:S104-12. J Med Assoc Thai. 1996. PMID: 9071074
-
Oncogenes related to head and neck cancer.Anticancer Res. 1993 Nov-Dec;13(6B):2541-51. Anticancer Res. 1993. PMID: 8135494 Review.
Cited by
-
Molecular pathogenesis of head and neck squamous cell carcinoma.Eur Arch Otorhinolaryngol. 2003 Oct;260(9):502-8. doi: 10.1007/s00405-003-0581-3. Epub 2003 May 8. Eur Arch Otorhinolaryngol. 2003. PMID: 12736744 Review.
-
Biological staging of head and neck cancer and its role in developing effective treatment strategies.Cancer Metastasis Rev. 1996 Mar;15(1):11-25. doi: 10.1007/BF00049485. Cancer Metastasis Rev. 1996. PMID: 8842477 Review.
-
Genomic imbalances in esophageal squamous cell carcinoma identified by molecular cytogenetic techniques.Genet Mol Biol. 2010 Apr;33(2):205-13. doi: 10.1590/S1415-47572010005000028. Epub 2010 Jun 1. Genet Mol Biol. 2010. PMID: 21637470 Free PMC article.
-
Identification of human renal cell carcinoma associated genes by suppression subtractive hybridization.Br J Cancer. 2001 Nov 2;85(9):1372-82. doi: 10.1054/bjoc.2001.2074. Br J Cancer. 2001. PMID: 11720477 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Medical
Research Materials
Miscellaneous