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. 1992 Oct;25(5):1065-71.

Genetic alterations in head and neck cancer

K D Somers  1 , G L Schechter
Affiliations
  • PMID: 1408191

Genetic alterations in head and neck cancer

K D Somers et al. Otolaryngol Clin North Am. 1992 Oct.

Abstract

Mutations of the ras gene family appear to be an uncommon genetic alteration in SCCHN. A common region of DNA amplification on chromosome 11q13 has been identified in SCCHN. A cluster of proto-oncogenes (int-2, hst-1, bcl-1, prad-1) has been localized to the 11q13 region. Studies are needed to determine the critical genes in 11q13 whose expression drive the amplicon. Mutations of the p53 tumor suppressor gene are the most common genetic alteration in SCCHN. The hope is that dysregulated oncogenes or tumor suppressor genes may be targets for specific therapy.

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