Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1992 Oct 1;89(19):9029-33.
doi: 10.1073/pnas.89.19.9029.

Protein tertiary structure recognition using optimized Hamiltonians with local interactions

R A Goldstein  1 , Z A Luthey-Schulten, P G Wolynes
Affiliations

Protein tertiary structure recognition using optimized Hamiltonians with local interactions

R A Goldstein et al. Proc Natl Acad Sci U S A. .

Abstract

Protein folding codes embodying local interactions including surface and secondary structure propensities and residue-residue contacts are optimized for a set of training proteins by using spin-glass theory. A screening method based on these codes correctly matches the structure of a set of test proteins with proteins of similar topology with 100% accuracy, even with limited sequence similarity between the test proteins and the structural homologs and the absence of any structurally similar proteins in the training set.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Biochemistry. 1991 Apr 30;30(17):4232-7 - PubMed
    1. Science. 1990 Nov 23;250(4984):1121-5 - PubMed
    1. J Mol Biol. 1991 Dec 20;222(4):1013-34 - PubMed
    1. Science. 1989 Oct 20;246(4928):371-3 - PubMed
    1. Proc Natl Acad Sci U S A. 1987 Nov;84(21):7524-8 - PubMed

Publication types

LinkOut - more resources