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Clinical Trial
. 1992 Sep;25(1):37-42.
doi: 10.1016/0167-8140(92)90193-x.

Pharmacokinetics of nicotinamide and its effect on blood pressure, pulse and body temperature in normal human volunteers

M R Stratford  1 , A Rojas, D W Hall, M F Dennis, S Dische, M C Joiner, R J Hodgkiss
Affiliations
Clinical Trial

Pharmacokinetics of nicotinamide and its effect on blood pressure, pulse and body temperature in normal human volunteers

M R Stratford et al. Radiother Oncol. 1992 Sep.

Abstract

The pharmacokinetics of nicotinamide were studied in four human volunteers after oral doses of 1-6 g. Plasma concentrations and clearance rates of the vitamin were found to be dose-dependent, with a half-life of approximately 7-9 h for the two highest doses administered (4 and 6 g), approximately 4 h with 2 g and approximately 1.5 h with a 1-g dose. Peak concentrations ranged from 0.7 to 1.1 mumol.ml-1 after a 6-g dose. The time to reach peak plasma concentration was dose independent with a broad range from 0.73 to 3 h. In this study, nicotinamide had no detectable effect on blood pressure, pulse or body temperature.

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