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. 1964 Mar 27;143(3613):1454-7.
doi: 10.1126/science.143.3613.1454.

ACTINOMYCIN D: SUPPRESSION OF RECOVERY IN X-IRRADIATED MAMMALIAN CELLS

M M ELKIND, G F WHITMORE, T ALESCIO

ACTINOMYCIN D: SUPPRESSION OF RECOVERY IN X-IRRADIATED MAMMALIAN CELLS

M M ELKIND et al. Science. .

Abstract

The lethal effect of two x-ray doses can be considerably enhanced if cultured cells are exposed to actinomycin D between doses. Net survival can be modified by temperature as well as actinomycin treatment. These effects are related to repair of sublethal damage and to cell kinetics between doses.

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