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. 1963 Dec;21(3):419-26.
doi: 10.1111/j.1476-5381.1963.tb02009.x.

AN ANTIHISTAMINE-LIKE SUBSTANCE (OR SUBSTANCES) IN EXTRACTS PREPARED FROM HUMAN TISSUES

B A KOVACS, G PELLETIER, B ROSE

AN ANTIHISTAMINE-LIKE SUBSTANCE (OR SUBSTANCES) IN EXTRACTS PREPARED FROM HUMAN TISSUES

B A KOVACS et al. Br J Pharmacol Chemother. 1963 Dec.

Abstract

A method for the extraction of an antihistamine-like substance (or substances) from human tissues is described. The method has demonstrated the presence of this active principle(s) in a large variety of human tissues, so far without exception. The substance(s) has a wide range of activity in antagonizing the in vitro effects of histamine, 5-hydroxytryptamine and bradykinin and the Schultz-Dale reaction on the guinea-pig ileum and rat uterus preparations.

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References

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