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. 1963 Dec;21(3):450-61.
doi: 10.1111/j.1476-5381.1963.tb02013.x.

THE ACTION OF HISTAMINE ON THE ISOLATED HEART

A L BARTLET

THE ACTION OF HISTAMINE ON THE ISOLATED HEART

A L BARTLET. Br J Pharmacol Chemother. 1963 Dec.

Abstract

A method is described for recording the coronary flow and the rate and the amplitude of contraction of an isolated heart maintained at constant temperature. Both histamine and noradrenaline increased the contractility of the guinea-pig heart. Pronethalol antagonized noradrenaline but not histamine. Mepyramine, 10-(2-pyrrolidin-1'-ylethyl)phenothiazine hydrochloride (pyrathiazine) and diphenhydramine reduced the contractility of the guinea-pig heart but did not antagonize the action of histamine. The influence of histamine and noradrenaline on coronary flow was variable but when the contractility of the heart increased there was a concomitant increase in coronary flow. Histamine decreased the contractility of the rat heart and the domestic fowl heart.

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References

    1. Arch Int Pharmacodyn Ther. 1962 May 1;137:116-20 - PubMed
    1. Naunyn Schmiedebergs Arch Exp Pathol Pharmakol. 1952;215(1-2):129-32 - PubMed
    1. J Pharm Pharmacol. 1956 Jan;8(1):18-26 - PubMed
    1. J Physiol. 1910 Dec 31;41(5):318-44 - PubMed
    1. J Physiol. 1954 Feb 26;123(2):260-76 - PubMed

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