doi: 10.1128/jb.129.2.967-972.1977.
Isolation of an Escherichia coli mutant deficient in thioredoxin reductase
- PMID: 14115
- PMCID: PMC235035
- DOI: 10.1128/jb.129.2.967-972.1977
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Isolation of an Escherichia coli mutant deficient in thioredoxin reductase
J Bacteriol.
1977 Feb.
Abstract
A mutant of Escherichia coli defective in thioredoxin reductase has been isolated and partially characterized. This mutant has no detectable thioredoxin reductase activity in vitro and yet it exhibits no in vivo defect in reduction of ribonucleotides. Evidence is presented that indicates that, in cells permeabilized via ether treatment, ribonucleoside diphosphate reduction can utilize glutathione as an alternate reducing system.
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