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. 1992 Nov;191(1):517-22.
doi: 10.1016/0042-6822(92)90223-c.

Cell receptor-independent infection by a neurotropic murine coronavirus

T M Gallagher  1 , M J Buchmeier, S Perlman
Affiliations

Cell receptor-independent infection by a neurotropic murine coronavirus

T M Gallagher et al. Virology. 1992 Nov.

Abstract

The cellular receptors for a coronavirus, mouse hepatitis virus (MHV), have been recently identified as one or more members of the carcinoembryonic antigen (CEA) family. The neurotropic JHM strain of MHV (MHV-JHM) possesses a highly fusogenic surface (S) glycoprotein. This protein is now shown to promote the spread of MHV into cells lacking the specific CEA-related MHV receptor. Resistant cells are recruited into MHV-induced syncytium with consequent production of progeny virus. Cell-to-cell spread of virus via membrane fusion without the requirement for specific cell surface receptor offers a novel way for virus to spread within infected hosts.

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