doi: 10.1126/science.144.3620.844.
SPLEEN-COLONY FORMATION IN ANEMIC MICE OF GENOTYPE WW
- PMID: 14149394
- DOI: 10.1126/science.144.3620.844
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SPLEEN-COLONY FORMATION IN ANEMIC MICE OF GENOTYPE WW
Science.
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Abstract
The hemopoietic cells from anemic mice of genotype WW are less able by 200-fold to take part in colony formationin the spleen than cells from the normal littermates of genotype ww. The genetic defect shows itself in the colony-forming cells, since cells from normal littermate mice formcolonies in the spleens of unirradiated mice of genotype WW. Use of animals of genotype WVVWT as recipients improves the spleen-colony method by removing bias resulting fromthe death of irradiated recipients.
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