Leukocyte count and risk of major coronary heart disease events
- PMID: 1415132
- DOI: 10.1093/oxfordjournals.aje.a116421
Leukocyte count and risk of major coronary heart disease events
Abstract
The association between leukocyte count and subsequent risk of major coronary heart disease events was examined using data from three prospective cohort studies--two from the United States and one from Great Britain. A total of 28,181 middle-aged men were followed for 6-12 years. A total of 1,768 men had a nonfatal myocardial infarction or died of coronary heart disease. In all three cohorts, there was a positive, statistically significant relation between baseline leukocyte count and risk of subsequent major coronary heart disease events after adjustment for age, serum total cholesterol, diastolic blood pressure, and number of cigarettes smoked per day (relative odds = 1.32 (p less than 0.0001), 1.15 (p = 0.0001), and 1.14 (p = 0.003), corresponding to a 2,000/mm3 difference in leukocyte count). The associations persisted when all nonsmokers (former smokers plus never smokers) and never smokers alone were considered and when those with evidence of preexisting coronary heart disease at baseline were excluded. Leukocyte count appears to be an indicator of a person's future risk of major coronary heart disease events.
Similar articles
-
The leukocyte count and risk of lung cancer.Cancer. 1992 Feb 1;69(3):680-4. doi: 10.1002/1097-0142(19920201)69:3<680::aid-cncr2820690314>3.0.co;2-d. Cancer. 1992. PMID: 1730118
-
Relative and absolute excess risks of coronary heart disease among women who smoke cigarettes.N Engl J Med. 1987 Nov 19;317(21):1303-9. doi: 10.1056/NEJM198711193172102. N Engl J Med. 1987. PMID: 3683458
-
The relationship of white blood cell count to other cardiovascular risk factors.Int J Epidemiol. 1990 Dec;19(4):881-8. doi: 10.1093/ije/19.4.881. Int J Epidemiol. 1990. PMID: 2084016
-
The white blood cell count and risk for coronary heart disease.Am Heart J. 1992 Jul;124(1):207-13. doi: 10.1016/0002-8703(92)90942-o. Am Heart J. 1992. PMID: 1615807 Review.
-
The atherosclerosis epidemic: methodology, nosology, and clinical practice.Am J Cardiol. 2001 Jul 19;88(2A):4E-7E. doi: 10.1016/s0002-9149(01)01709-x. Am J Cardiol. 2001. PMID: 11473736 Review.
Cited by
-
Evaluation of various hematological parameters in patients with periodontitis after nonsurgical therapy at different intervals.J Indian Soc Periodontol. 2016 Mar-Apr;20(2):180-3. doi: 10.4103/0972-124X.175172. J Indian Soc Periodontol. 2016. PMID: 27143831 Free PMC article.
-
Components of the complete blood count as risk predictors for coronary heart disease: in-depth review and update.Tex Heart Inst J. 2013;40(1):17-29. Tex Heart Inst J. 2013. PMID: 23467296 Free PMC article. Review.
-
Impaired signaling intrinsic to sinoatrial node pacemaker cells affects heart rate variability during cardiac disease.J Clin Trials. 2014 Mar;4(1):152. doi: 10.4172/2167-0870.1000152. J Clin Trials. 2014. PMID: 26251764 Free PMC article.
-
Physiological correlates of bereavement and the impact of bereavement interventions.Dialogues Clin Neurosci. 2012 Jun;14(2):129-39. doi: 10.31887/DCNS.2012.14.2/tbuckley. Dialogues Clin Neurosci. 2012. PMID: 22754285 Free PMC article. Review.
-
Low grade inflammation and coronary heart disease: prospective study and updated meta-analyses.BMJ. 2000 Jul 22;321(7255):199-204. doi: 10.1136/bmj.321.7255.199. BMJ. 2000. PMID: 10903648 Free PMC article.
Publication types
MeSH terms
LinkOut - more resources
Full Text Sources