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. 1964 Aug 21;145(3634):817-9.
doi: 10.1126/science.145.3634.817.

NICOTONIC ACID BIOSYNTHESIS: CONTROL BY AN ENZYME THAT COMPETES WITH A SPONTANEOUS REACTION

A H MEHLER, K YANO, E L MAY

NICOTONIC ACID BIOSYNTHESIS: CONTROL BY AN ENZYME THAT COMPETES WITH A SPONTANEOUS REACTION

A H MEHLER et al. Science. .

Abstract

Extracts of livers from diabetic rats contain normal amounts of the enzymes needed to convert 3-hydroxyanthranilic acid to nicotinic acid nucleotide. The decreased capacity of diabetic animals to synthesize nicotinic acid is therefore attributed to increased amounts of picolinic carboxylase, which competes for a common intermediate with the spontaneous reaction in which quinolinic acid is formed as a precursor of nicotinic acid. These studies were facilitated by the synthesis of 3-hydroxyanthranilic acid labeled with carbon-14 in positions 3 and 6

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