HUMAN ERYTHROCYTE LACTATE DEHYDROGENASE: 4 GENETICALLY DETERMINED VARIANTS

Abstract

Four variants of human erythrocyte lactate dehydrogenase (LDH) are described. One of these is similar to the one previously described by Boyer and is interpreted as a variant of LDH-B. The other three are thought to represent variants of LDH-A. Studies of families indicate that LDH-A and LDH-B are under separate genetic control and are inherited as autosomal co-dominants. Evidence is presented that the LDH-A locus is not closely linked to the loci for the ABH and Duffy blood group systems.