doi: 10.1111/j.1749-6632.1992.tb42592.x.
Use of magnetic resonance imaging to analyze the performance of hollow-fiber bioreactors
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- PMID: 1416611
- DOI: 10.1111/j.1749-6632.1992.tb42592.x
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Use of magnetic resonance imaging to analyze the performance of hollow-fiber bioreactors
Ann N Y Acad Sci.
.
Abstract
Preliminary experiments were described that demonstrate that MRI is an effective tool for the noninvasive study of hollow-fiber bioreactors. Flow-compensated velocity-encoding pulse sequences were successively applied to analyze the velocity patterns in a module operated without cells, with an artificially induced flow field perturbation. Diffusion damping pulse sequences were also used to spatially resolve regions of cell growth in a bioreactor. These experiments provide the necessary basis from which future flow and spectroscopic studies can be conducted.
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