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. 1992 Oct 13:665:285-300.
doi: 10.1111/j.1749-6632.1992.tb42592.x.

Use of magnetic resonance imaging to analyze the performance of hollow-fiber bioreactors

C Donoghue  1 , M Brideau, P Newcomer, B Pangrle, D DiBiasio, E Walsh, S Moore
Affiliations

Use of magnetic resonance imaging to analyze the performance of hollow-fiber bioreactors

C Donoghue et al. Ann N Y Acad Sci. .

Abstract

Preliminary experiments were described that demonstrate that MRI is an effective tool for the noninvasive study of hollow-fiber bioreactors. Flow-compensated velocity-encoding pulse sequences were successively applied to analyze the velocity patterns in a module operated without cells, with an artificially induced flow field perturbation. Diffusion damping pulse sequences were also used to spatially resolve regions of cell growth in a bioreactor. These experiments provide the necessary basis from which future flow and spectroscopic studies can be conducted.

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