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. 1992 Aug;36(8):1788-90.
doi: 10.1128/AAC.36.8.1788.

In vitro susceptibilities of Borrelia burgdorferi to five oral cephalosporins and ceftriaxone

W A Agger  1 , S M Callister, D A Jobe
Affiliations

In vitro susceptibilities of Borrelia burgdorferi to five oral cephalosporins and ceftriaxone

W A Agger et al. Antimicrob Agents Chemother. 1992 Aug.

Abstract

We determined the in vitro susceptibilities of eight Borrelia burgdorferi isolates to five oral cephalosporins. MICs for B. burgdorferi 297 were 23 micrograms/ml (cephalexin), 45 micrograms/ml (cefadroxil), 91 micrograms/ml (cefaclor), 0.13 microgram/ml (cefuroxime), 0.8 microgram/ml (cefixime), and 0.02 microgram/ml (ceftriaxone). When B. burgdorferi isolates were exposed to concentrations twice the MIC of cefuroxime, cefixime, or ceftriaxone, at least 72 h of incubation was required to kill 99% of the organisms.

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