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. 1992 Sep;36(9):2042-5.
doi: 10.1128/AAC.36.9.2042.

Inhibition of intrahepatic hepatitis B virus replication by antiviral drugs in a novel transgenic mouse model

T Nagahata  1 , K Araki, K Yamamura, K Matsubara
Affiliations

Inhibition of intrahepatic hepatitis B virus replication by antiviral drugs in a novel transgenic mouse model

T Nagahata et al. Antimicrob Agents Chemother. 1992 Sep.

Abstract

Transgenic mice which carry the integrated human hepatitis B virus (HBV) genome and produce HBV particles in the liver were treated with antiviral compounds, and the amount of viral DNA in the liver and serum was monitored by Southern analyses. Mouse alpha interferon (200,000 U per injection, twice daily for 3 days) and a novel nucleoside, oxetanocin G (15 mg/kg of body weight per injection, twice daily for 7 days), inhibited viral DNA synthesis in the liver almost completely. This animal model should prove useful in evaluating anti-HBV agents.

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References

    1. Antimicrob Agents Chemother. 1978 Jan;13(1):53-60 - PubMed
    1. Lancet. 1981 Nov 21;2(8256):1129-33 - PubMed
    1. Virology. 1989 Mar;169(1):213-6 - PubMed
    1. J Antibiot (Tokyo). 1987 Dec;40(12):1788-90 - PubMed
    1. Nature. 1985 Oct 10-16;317(6037):489-95 - PubMed

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