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. 1992 Sep;36(9):2054-6.
doi: 10.1128/AAC.36.9.2054.

Pseudomonas aeruginosa biofilm as a diffusion barrier to piperacillin

B D Hoyle  1 , J Alcantara, J W Costerton
Affiliations

Pseudomonas aeruginosa biofilm as a diffusion barrier to piperacillin

B D Hoyle et al. Antimicrob Agents Chemother. 1992 Sep.

Abstract

Pseudomonas aeruginosa 579 biofilms formed on dialysis membranes retarded piperacillin diffusion. Treatment of biofilms with 5.0 mM CaCl2.2H2O prevented diffusion. Biofilms permitted equilibration of [14C]glucose. Thin-layer chromatography of fluids distal to untreated (viable and nonviable) and viable Ca(2+)-treated P. aeruginosa 579 biofilms and fluids distal to a viable P. aeruginosa mutant noninducible for the expression of beta-lactamase did not detect piperacillinoic acid.

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