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. 1964 Sep 25;145(3639):1427-9.
doi: 10.1126/science.145.3639.1427.

HOMOGRAFT TARGET CELLS: SPECIFIC DESTRUCTION IN VITRO BY CONTACT INTERACTION WITH IMMUNE MACROPHAGES

G A GRANGER, R S WEISER

HOMOGRAFT TARGET CELLS: SPECIFIC DESTRUCTION IN VITRO BY CONTACT INTERACTION WITH IMMUNE MACROPHAGES

G A GRANGER et al. Science. .

Abstract

Specific adherence and mutual immunologic destruction occurred after contact in vitro of immune peritoneal macrophages from C57BI/6K mice with homograft target cells from A/Jax mice. Cell destruction apparently resulted from a nonphagocytic mechanism involving cell contact rather than humoral antibody. Cell destruction was determined by a plaque technique with either immunecells or target cells as monolayers.

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