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. 1964 Oct 16;146(3642):400-1.
doi: 10.1126/science.146.3642.400.

SUBCLASSES OF HUMAN GAMMA-2-GLOBULIN BASED ON DIFFERENCES IN THE HEAVY POLYPEPTIDE CHAINS

W D TERRY, J L FAHEY

SUBCLASSES OF HUMAN GAMMA-2-GLOBULIN BASED ON DIFFERENCES IN THE HEAVY POLYPEPTIDE CHAINS

W D TERRY et al. Science. .

Abstract

Three subclasses of human gamma(2)-globulin (IgG) molecules were detected in normal human serum with antiserums prepared in monkeys. These subclasses, designated gamma(2a)-, gamma(2b)-, and gamma(2c)-globulins, have antibody activity. The distinguishing antigenic characteristics of each subclass were associated with the heavy polypeptide chains and the F (fast) fragments resulting from treatment of gamma(2)-globulins with papain.

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