Review
doi: 10.1016/0952-7915(92)90072-m.
New insights into T-cell antigen receptor structure and signal transduction
Affiliations
- PMID: 1418701
- DOI: 10.1016/0952-7915(92)90072-m
Item in Clipboard
Review
New insights into T-cell antigen receptor structure and signal transduction
Curr Opin Immunol.
1992 Jun.
Abstract
Recent studies have provided insights into how the complex structure of the T-cell antigen receptor relates to its signal transduction function. Both the CD3 and zeta subunits contain functioning signaling modules that regulate the activation of tyrosine kinases and phosphorylation of cellular substrates.
Similar articles
-
Molecular and genetic insights into the role of protein tyrosine kinases in T cell receptor signaling.Clin Immunol Immunopathol. 1995 Sep;76(3 Pt 2):S158-62. doi: 10.1016/s0090-1229(95)90054-3. Clin Immunol Immunopathol. 1995. PMID: 7554459 Review. No abstract available.
-
The role of protein tyrosine kinases and protein tyrosine phosphatases in T cell antigen receptor signal transduction.Annu Rev Immunol. 1994;12:555-92. doi: 10.1146/annurev.iy.12.040194.003011. Annu Rev Immunol. 1994. PMID: 8011291 Review.
-
An evolutionary and structural perspective on T cell antigen receptor function.Immunol Rev. 2003 Feb;191:7-27. doi: 10.1034/j.1600-065x.2003.00016.x. Immunol Rev. 2003. PMID: 12614348 Review.
-
The protein interactions of the immunoglobulin receptor family tyrosine-based activation motifs present in the T cell receptor zeta subunits and the CD3 gamma, delta and epsilon chains.Eur J Immunol. 1996 May;26(5):1063-8. doi: 10.1002/eji.1830260516. Eur J Immunol. 1996. PMID: 8647168
-
Qualitatively distinct signaling through T cell antigen receptor subunits.Eur J Immunol. 1997 Mar;27(3):707-16. doi: 10.1002/eji.1830270320. Eur J Immunol. 1997. PMID: 9079813
Cited by
-
itk, a T-cell-specific tyrosine kinase gene inducible by interleukin 2.Proc Natl Acad Sci U S A. 1992 Dec 1;89(23):11194-8. doi: 10.1073/pnas.89.23.11194. Proc Natl Acad Sci U S A. 1992. PMID: 1280821 Free PMC article.
-
Multivalent structure of an alphabetaT cell receptor.Proc Natl Acad Sci U S A. 1999 Feb 16;96(4):1547-52. doi: 10.1073/pnas.96.4.1547. Proc Natl Acad Sci U S A. 1999. PMID: 9990061 Free PMC article.
-
Increased proportion of responders to a murine anti-CD3 monoclonal antibody of the IgG1 class in patients with systemic lupus erythematosus (SLE).Clin Exp Immunol. 1993 Dec;94(3):423-8. Clin Exp Immunol. 1993. PMID: 8252802 Free PMC article.
-
GRB2 and phospholipase C-gamma 1 associate with a 36- to 38-kilodalton phosphotyrosine protein after T-cell receptor stimulation.Mol Cell Biol. 1994 Jul;14(7):4435-42. doi: 10.1128/mcb.14.7.4435-4442.1994. Mol Cell Biol. 1994. PMID: 7516467 Free PMC article.
-
Targeting of T lymphocytes to melanoma cells through chimeric anti-GD3 immunoglobulin T-cell receptors.Neoplasia. 2000 Sep-Oct;2(5):449-59. doi: 10.1038/sj.neo.7900108. Neoplasia. 2000. PMID: 11191112 Free PMC article.
Publication types
MeSH terms
Substances
Grants and funding
LinkOut - more resources
Full Text Sources
Other Literature Sources
