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. 1992;249(6):318-21.
doi: 10.1007/BF00179380.

Kinin generation following methacholine nasal airway challenge of non-allergic subjects

C R Baumgarten  1 , W Niemz, G Kunkel
Affiliations

Kinin generation following methacholine nasal airway challenge of non-allergic subjects

C R Baumgarten et al. Eur Arch Otorhinolaryngol. 1992.

Abstract

Following nasal challenges with the muscarinic neurotransmitter methacholine in 14 patients with chronic non-allergic rhinitis, kinin generation was induced. This occurrence was inhibited by pretreatment with anticholinergic agents (ipratropium bromide) and by an overdose of neurotransmitter, indicating that a muscarinic receptor is stimulating the liberation of kinin. These observations suggest that patients with chronic non-allergic rhinitis exhibit cholinergic neurotransmitter-induced kinin generation.

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