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Review
. 1992 Aug;4(4):684-95.
doi: 10.1016/0955-0674(92)90090-y.

Membrane transport proteins: implications of sequence comparisons

J K Griffith  1 , M E Baker, D A Rouch, M G Page, R A Skurray, I T Paulsen, K F Chater, S A Baldwin, P J Henderson
Affiliations
Review

Membrane transport proteins: implications of sequence comparisons

J K Griffith et al. Curr Opin Cell Biol. 1992 Aug.

Abstract

Analyses of the sequences and structures of many transport proteins that differ in substrate specificity, direction of transport and mechanism of transport suggest that they form a family of related proteins. Their sequence similarities imply a common mechanism of action. This hypothesis provides an objective basis for examining their mechanisms of action and relationships to other transporters.

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