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. 1964 May 1;144(3618):552-3.
doi: 10.1126/science.144.3618.552.

HEMOGLOBINS A AND F: FORMATION IN THALASSEMIA AND OTHER HEMOLYTIC ANEMIAS

P A MARKS, E R BURKA

HEMOGLOBINS A AND F: FORMATION IN THALASSEMIA AND OTHER HEMOLYTIC ANEMIAS

P A MARKS et al. Science. .

Abstract

Rates of synthesis of hemoglobin A by erythroid cells from thalassemic subjects are markedly decreased. Formation of hemoglobin F, however, proceeds at similar rates in cells from subjects with thalassemia and other types of hemolytic anemias. A mechanism is suggested regarding the altered patterns of hemoglobin synthesis under conditions of erythropoietic stimulation in subjects with and without thalassemia.

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