Comparative Study
[Quantitative characteristics of interactions of blood lipoproteins and steroid hormones]
[Article in
Russian]
- PMID: 1421302
Item in Clipboard
Comparative Study
[Quantitative characteristics of interactions of blood lipoproteins and steroid hormones]
[Article in
Russian]
Biull Eksp Biol Med.
1992 Jul.
Abstract
Human and serum lipoproteins interaction with steroid hormones (corticosterone and hydrocortisone) were studied. Methods of fluorescence quenching titration and equilibrium dialysis were used for quantitative evaluation of VLDL, LDL and HDL glucocorticoids binding ability. Association constants were found to be 0.6-2.0 x 10 M for corticosterone and 4.0-8.0 x 10 M for hydrocortisone. The number of binding sites ranged from 3 to 300 for different classes of lipoproteins. Our data suggest high specificity of serum lipoproteins binding with corticosterone and hydrocortisone.
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