Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1992;22(1):31-8.
doi: 10.1007/BF01833331.

Expression of IGF-I and IGF-II mRNA in breast tissue

S Paik  1
Affiliations

Expression of IGF-I and IGF-II mRNA in breast tissue

S Paik. Breast Cancer Res Treat. 1992.

Abstract

Expression of IGF-I and IGF-II was studied in human breast cancer tissues by in situ hybridization. IGF-I mRNA was detected only in stromal cells adjacent to normal breast epithelial cells. Stromal cells associated with the tumor cells did not contain IGF-I, nor did malignant or benign breast epithelial cells. In contrast, IGF-II mRNA was found in both the malignant epithelial cells and their adjacent stromal cells. These data imply that stromal cells associated with breast epithelium may switch expression from IGF-I to IGF-II during breast cancer evolution. This appearance of IGF-II expression may identify cancer-associated stromal cells that have a fetal phenotype.

PubMed Disclaimer

References

    1. Cancer Res. 1988 Dec 1;48(23):6691-6 - PubMed
    1. J Biol Chem. 1992 May 5;267(13):9000-4 - PubMed
    1. Mol Endocrinol. 1989 Mar;3(3):509-17 - PubMed
    1. Lab Invest. 1989 Nov;61(5):522-6 - PubMed
    1. Am J Pathol. 1989 Mar;134(3):597-603 - PubMed

Substances

LinkOut - more resources