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Review
. 1992 Fall;4(4):454-7.
doi: 10.1176/jnp.4.4.454.

Prolonged postictal encephalopathy in two patients with clozapine-induced seizures

L P Karper  1 , S P Salloway, J P Seibyl, J H Krystal
Affiliations
Review

Prolonged postictal encephalopathy in two patients with clozapine-induced seizures

L P Karper et al. J Neuropsychiatry Clin Neurosci. 1992 Fall.

Abstract

Two patients with prolonged postictal encephalopathy lasting 63 and 72 hours, respectively, following seizures with clozapine are reported. Clozapine alters the EEG in a majority of patients treated, with seizure frequency as high as 5-10% in doses above 600 mg/d. Prolonged postictal encephalopathy following a clozapine-induced seizure has not been previously reported but may be an important side effect of this medication. Pharmacologic and clinical issues are discussed.

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