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. 1977 Jun;74(6):2241-5.
doi: 10.1073/pnas.74.6.2241.

Uncouplers and the molecular mechanism of uncoupling in mitochondria

R J Kessler, H Vande Zande, C A Tyson, G A Blondin, J Fairfield, P Glasser, D E Green

Uncouplers and the molecular mechanism of uncoupling in mitochondria

R J Kessler et al. Proc Natl Acad Sci U S A. 1977 Jun.

Abstract

Uncouplers are molecules with protonophoric and ionophoric capabilities that mediate coupled cyclical transport of cations--a transport that takes precedence over all other coupled processes. Uncouplers form cation-containing complexes with electrogenic ionophores that potentiate cyclical transport of cations. The molecular mechanism of uncoupling sheds strong light on the mechanism of coupling.

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References

    1. Biochim Biophys Acta. 1975 Jun 17;387(3):507-18 - PubMed
    1. Proc Natl Acad Sci U S A. 1976 Sep;73(9):3141-5 - PubMed
    1. J Biol Chem. 1953 Mar;201(1):357-70 - PubMed
    1. J Biol Chem. 1976 Aug 25;251(16):5069-77 - PubMed
    1. Biochem Biophys Res Commun. 1963 Jun 20;11:441-6 - PubMed

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