doi: 10.1016/0165-3806(92)90130-o.
A molecular recognizing system of serotonin in rat fetal axonal growth cones: uptake and high affinity binding
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- PMID: 1424085
- DOI: 10.1016/0165-3806(92)90130-o
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A molecular recognizing system of serotonin in rat fetal axonal growth cones: uptake and high affinity binding
Brain Res Dev Brain Res.
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Abstract
Axonal growth cone particles (AGCP) isolated from prenatal and postnatal rat brain had different high-affinity 5-HT uptake characteristics. In postnatal AGCP the uptake behaves as in the adult rat brain, while in the prenatal AGCP the uptake characteristics seem to be in a transitional stage. Also in prenatal AGCP we observed specific, high-affinity 5-HT binding sites. These results support the idea of an important role for 5-HT during axogenesis.
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