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. 1965 Mar 12;147(3663):1307-8.
doi: 10.1126/science.147.3663.1307.

BURSA OF FABRICIUS IN CHICKENS: POSSIBLE HUMORAL FACTOR

R L STPIERRE, G A ACKERMAN

BURSA OF FABRICIUS IN CHICKENS: POSSIBLE HUMORAL FACTOR

R L STPIERRE et al. Science. .

Abstract

Chicks bursectomized by testosterone injection on the 5th day of incubation showed a marked inability to produce antibodies to Salmonella typhimurium. When portions of the bursa of Fabricius were enclosed in cell-impermeable Millipore diffusion chambers and implanted subcutaneously or intraperitoneally, the antibody-producing capacity of these animals was restored. Evidence strongly suggests that the bursa of Fabricius elaborates a non-cellular agent capable of restoring immunologic reactivity in bursectomized chicks.

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