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. 1965 Jan 1;121(1):125-32.
doi: 10.1084/jem.121.1.125.

ONSET AND DURATION OF DNA SYNTHESIS IN ANTIBODY FORMING CELLS AFTER ANTIGEN

E P COHEN, D W TALMAGE

ONSET AND DURATION OF DNA SYNTHESIS IN ANTIBODY FORMING CELLS AFTER ANTIGEN

E P COHEN et al. J Exp Med. .

Abstract

Within 5 hours after the intravenous injection of particulate antigen into the primarily immunized mouse, precursors of antibody-forming cells began DNA synthesis as shown by the incorporation of tritium-labeled thymidine. DNA synthesis continued for at least 24 hours and essentially stopped by 48 hours. No DNA synthesis in antibody-forming precursor cells occurred before the injection of antigen.

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