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. 1965 Apr 2;148(3666):97-8.
doi: 10.1126/science.148.3666.97.

COXSACKIE A9 VIRUS: MUTATION FROM DRUG DEPENDENCE TO DRUG INDEPENDENCE

H J EGGERS, I TAMM

COXSACKIE A9 VIRUS: MUTATION FROM DRUG DEPENDENCE TO DRUG INDEPENDENCE

H J EGGERS et al. Science. .

Abstract

During the multiplication of Coxsackie A9 virus dependent on 2 - (alpha - hydroxybenzyl) - benzimidazole there arise some drug-independent virus particles, which are either drug-resistant or drug-sensitive. We studied the properties of such revertant particles under conditions which did not favor the selection of resistant over sensitive virus particles. These particles exhibited a wide range of responses to 2-(alpha-hydroxybenzyl)-benzimidazole, from high sensitivity to high resistance. Subclones showed the same degree of sensitivity or resistance as the respective parent clones.

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