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. 1992 Aug 25;219(2):345-6.
doi: 10.1016/0014-2999(92)90319-y.

Cocaine place preference is blocked by the delta-opioid receptor antagonist, naltrindole

K Menkens  1 , E J Bilsky, K D Wild, P S Portoghese, L D Reid, F Porreca
Affiliations

Cocaine place preference is blocked by the delta-opioid receptor antagonist, naltrindole

K Menkens et al. Eur J Pharmacol. .

Abstract

Naltrindole, a selective delta-opioid receptor antagonist, was evaluated for its potential to block the reinforcing properties of cocaine using a conditioned place pairing paradigm in Lewis rats. Cocaine HCl (15 mg/kg s.c.) produced a strong place preference which was significantly blocked in animals pretreated with naltrindole (3 mg/kg i.p.); naltrindole alone showed no reinforcing or aversive effects. The results suggest a novel approach for the treatment of cocaine abuse in man.

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