[The role of plasma fibronectin in the pathogenesis of post- aggressive conditions]

Abstract

The interrelations of changes in plasma fibronectin (FN) level, hemostatic parameters and RES function were studied in the time course of traumatic or burn disease. A combination of interdependent disorders in the systems studied reflecting features of varying periods of extreme states was established in rat experiments. The analysis of the data obtained has suggested that FN is involved in the pathologic process and participates in the pathogenesis of shock and its complications by interacting with hemostasis and RES as a mediator thus playing an important role in maintaining the level of nonspecific body resistance.