doi: 10.1111/j.1365-4362.1992.tb04011.x.
Topical corticosteroids: quality control considerations
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- PMID: 1428466
- DOI: 10.1111/j.1365-4362.1992.tb04011.x
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Topical corticosteroids: quality control considerations
Int J Dermatol.
1992 Oct.
Abstract
A simple procedure is developed, which can be used as a quality control test. The method utilizes commercially available diffusion cell assembly, synthetic membrane, and an appropriate receptor phase. The amount of drug released over time is determined using an HPLC method. From this, the drug release rate, flux, microgram/cm2/min0.5 is calculated. This drug release rate can serve as a good quality control test to assure batch-to-batch uniformity.
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