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Clinical Trial
. 1992 Aug;161(8):493-7.
doi: 10.1007/BF02942121.

Indomethacin and ethamsylate alone and in combination for the relief of post episiotomy pain

R F Harrison  1 , M Devitt
Affiliations
Clinical Trial

Indomethacin and ethamsylate alone and in combination for the relief of post episiotomy pain

R F Harrison et al. Ir J Med Sci. 1992 Aug.

Abstract

In a bid to minimise dosage and possible side-effects when relieving post episiotomy pain, the NSAID Indomethacin was studied in combination with a systemic haemostat Ethamsylate which has been shown to selectively inhibit some prostaglandins. Comparative groups also took Indomethacin alone and placebo in a double blind non-crossover comparison. Efficacy was judged in terms of side-effects and assessments of pain intensity, pain relief and global assessment of pain. There was some evidence of a beneficial interaction between Indomethacin and Ethamsylate when adjustments were made for the patient's age and initial pain score. Side-effects were most common in the combination therapy group.

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