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. 1965 Jun 11;148(3676):1477-9.
doi: 10.1126/science.148.3676.1477.

PARTICLES RESEMBLING PAPOVA VIRUSES IN HUMAN CEREBRAL DEMYELINATING DISEASE

G ZURHEIN, S M CHOU

PARTICLES RESEMBLING PAPOVA VIRUSES IN HUMAN CEREBRAL DEMYELINATING DISEASE

G ZURHEIN et al. Science. .

Abstract

Degenerated brain tissue obtained from a deceased patient who had progressive multifocal leukoencephalopathy had been fixed in formalin prior to processing for electron microscopy. In ultrathin sections virus-like particles resembling papova virions were frequently observed in glial nuclei. Correlation with light-microscopy findings suggests that demyelination resulted from the cytocidal effect of the virus on oligodendroglia.

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