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. 1977 Jun 27;89(2):113-8.
doi: 10.1007/BF00308512.

Carcinogenic activity of anthanthrene on mouse skin

E Cavalieri, P Mailander, A Pelfrene

Carcinogenic activity of anthanthrene on mouse skin

E Cavalieri et al. Z Krebsforsch Klin Onkol Cancer Res Clin Oncol. .

Abstract

Dibenzo [cd,jk] pyrene (anthanthrene), considered to be noncarcinogenic, was examined for carcinogenicity in a comparative study with other polycyclic hydrocarbons. Anthanthrene induced benign and malignant epidermal neoplasms in female Swiss mice after repeated skin application. The incidence of these tumors (47%) was lower and the latency longer than those found after benzo[a]pyrene or dibenzo[a,h]pyrene treatment. Since the proportion of malignant neoplasms was similar (60%) in these three groups, the results indicate that anthanthrene is a relatively strong carcinogen. A rationale accounting for previous negative results in percutaneous experiments with this compound is suggested.

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