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. 1977 Jun 27;89(2):137-43.
doi: 10.1007/BF00308514.

Hepatocarcinogenetic effect of DENA in pigs

J J Graw, H Berg

Hepatocarcinogenetic effect of DENA in pigs

J J Graw et al. Z Krebsforsch Klin Onkol Cancer Res Clin Oncol. .

Abstract

DENA was fed to Göttingen mini-pigs at a dose of 0.4 mg/kg body weight with a total dosage of 420 mg/kg over an experimental period of five years. The animals showed multiple neoplasia of the liver with all transitions, including hepatocellular carcinoma and Kupffer-cell sarcoma with metastases in the regional lymph nodes and the lung. Two animals had metastases in the lung as well as one renal carcinoma and one tumor in the hemisphere of the brain.

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