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. 1965 Aug 13;149(3685):754-6.
doi: 10.1126/science.149.3685.754.

ADENOVIRUS-ASSOCIATED DEFECTIVE VIRUS PARTICLES

R W ATCHISON, B C CASTO, W M HAMMON

ADENOVIRUS-ASSOCIATED DEFECTIVE VIRUS PARTICLES

R W ATCHISON et al. Science. .

Abstract

Small, DNA-containing particles were separated from preparations of a simian adenovirus. These particles differed antigenically from the adenovirus. Replication of the particles in cell cultures was obtained only when theywere inoculated simultaneously with adenoviruses. This suggests that these adenovirus-associated particles behave as defective viruses.

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