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. 1992 Sep;19(9):1371-6.

99mTc human immunoglobulin scintigraphy--a reliable method to detect joint activity in rheumatoid arthritis

M H de Bois  1 , J W Arndt, E A van der Velde, P A van der Lubbe, M L Westedt, E K Pauwels, F C Breedveld
Affiliations
  • PMID: 1433003

99mTc human immunoglobulin scintigraphy--a reliable method to detect joint activity in rheumatoid arthritis

M H de Bois et al. J Rheumatol. 1992 Sep.

Abstract

The ability of 99mtechnetium labelled nonspecific, polyclonal human immunoglobulin G (99mTc-IgG) scintigraphy to depict and quantify synovial inflammation was studied in 30 patients with rheumatoid arthritis (RA). All patients were injected with 350 MBq 99mTc-IgG and imaging was performed 4 h later. This resulted in excellent images of inflamed synovium. Scores for 99mTc-IgG joint scintigraphy correlated highly with scores for joint swelling and C-reactive protein levels, weakly with pain scores and not with radiographic scores of joint destruction. These results suggest that 99mTc-IgG joint scintigraphy may provide an objective test to detect synovitis and measure the activity of the disease.

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