doi: 10.1126/science.149.3684.645.
ABNORMAL IMMUNE MECHANISM IN ALLOGENEIC RADIATION CHIMERAS
- PMID: 14331188
- DOI: 10.1126/science.149.3684.645
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ABNORMAL IMMUNE MECHANISM IN ALLOGENEIC RADIATION CHIMERAS
Science.
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Abstract
Mice were subjected to x-rays (950 roentgens) and injected with isogeneic (isologous) or allogeneic (homnologous) bone marrow. Six to 8 months later these chimeras were injected with Salmonella typhi flagellar antigen, and the formation of antibodies resistant and sensitive to destruction by treatment in vitro with 2-mercaptoethanol was determined. The allogeneic chimeras showed almost normal amounts of serumn antibody after a third injection of antigen but a relative defect in their ability to synthesize antibody resistant to 2-mercaptoethanol. Apparently control of antibody formation becomes abnormal in the presence of the immunologic tolerance existing between the host and the foreign hematopoietic graft.
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