doi: 10.1021/jm00099a014.
Synthesis and biological activity of 13-epi-avermectins: potent anthelmintic agents with an increased margin of safety
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- PMID: 1433196
- DOI: 10.1021/jm00099a014
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Synthesis and biological activity of 13-epi-avermectins: potent anthelmintic agents with an increased margin of safety
J Med Chem.
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Abstract
Chemical conversion of the potent anthelmintic natural products avermectin B1 (1) and avermectin B2 (3) to the corresponding 13-epi analogs (15 and 9) is described. The novel analogs retain the full potency of the natural products but are substantially safer.
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