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. 1992 Oct 16;35(21):3873-8.
doi: 10.1021/jm00099a014.

Synthesis and biological activity of 13-epi-avermectins: potent anthelmintic agents with an increased margin of safety

T A Blizzard  1 , G M Margiatto, H Mrozik, W L Shoop, R A Frankshun, M H Fisher
Affiliations

Synthesis and biological activity of 13-epi-avermectins: potent anthelmintic agents with an increased margin of safety

T A Blizzard et al. J Med Chem. .

Abstract

Chemical conversion of the potent anthelmintic natural products avermectin B1 (1) and avermectin B2 (3) to the corresponding 13-epi analogs (15 and 9) is described. The novel analogs retain the full potency of the natural products but are substantially safer.

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