Case Reports
doi: 10.1136/jmg.29.10.699.
A non-isotopic in situ hybridisation study of the chromosomal origin of 15 supernumerary marker chromosomes in man
Affiliations
- PMID: 1433228
- PMCID: PMC1016126
- DOI: 10.1136/jmg.29.10.699
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Case Reports
A non-isotopic in situ hybridisation study of the chromosomal origin of 15 supernumerary marker chromosomes in man
J Med Genet.
1992 Oct.
Abstract
Fifteen patients presenting with mosaic or non-mosaic karyotypes containing a distamycin-DAPI negative de novo or familial supernumerary marker chromosome were studied with non-isotopic in situ hybridisation using a library of alphoid centromere specific and satellite II/III probes. The in situ hybridisation studies showed that seven markers were derived from satellited autosomes (three chromosome 13/21, two chromosome 14, two chromosome 22), six from non-satellited autosomes (two chromosome 4, one chromosome 12, one chromosome 16, two chromosome 19), and one from the Y chromosome. One non-mosaic marker was negative for all the alphoid and satellite II/III probes used.
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